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ea0026p64 | Endocrine tumours and neoplasia | ECE2011

Primary hyperparathyroidism in MEN1 patients: preferred surgical procedure and relation with genotype

Pieterman C R C , van Hulsteijn L T , den Heijer M , van der Luijt R B , Hermus A R M M , Vriens M R , Valk G D

Background: Primary hyperparathyroidism (pHPT) is the most prevalent manifestation of multiple endocrine neoplasia type 1 (MEN1). Surgery is the preferred treatment but which type of surgery offers the best chance of cure combined with the lowest risk of postoperative hypoparathyroidism is still uncertain.Aims: Identifying the optimal surgical technique for MEN1 related pHPT. Describing the course of postoperative hypoparathyroidism. To see if a genotype...

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ea0026p456 | Thyroid cancer | ECE2011

Thr300Ala ATG16L1 polymorphism influences susceptibility to and the prognosis of epithelial cell derived thyroid carcinoma

Huijbers A , Plantinga T S , Oosting M , Joosten L A B , Aben K K H , Netea M G , Hermus A R M M , Netea-Maier R T

Background: Loss of autophagy protein ATG16L1 enhances endotoxin-induced interleukin 1β (IL1β) production. IL1β has been found to have antineoplastic effects in thyroid malignancies. We hypothesized that a missense polymorphism in ATG16L1 autophagy gene (Thr300Ala) results in changes in the function of the molecule and influences susceptibility to and prognosis of epithelial cell derived thyroid carcinoma (TC).Objective: i) To assess the f...

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ea0026p237 | Pituitary | ECE2011

Quality of life is impaired in association with the need for prolonged postoperative therapy by somatostatin analogs in patients with acromegaly

Postma M R , Netea-Maier R T , van den Berg G , Homan J , Sluiter W J , van den Bergh A C M , Wolffenbuttel B H R , Hermus A R M M , van Beek A P

Objective: To assess the influence of use of long-acting somatostatin analogs on long-term health-related quality of life (HR-QoL) in relation to disease control in patients surgically-treated for acromegaly.Design: Cross-sectional study in two University Medical Centers in The Netherlands.Patients: One hundred and eight patients (47 m/61 f, mean age 54±11 years) with a minimal follow up period of 1 year after pituitary surger...

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Endocrine Abstracts

Primary hyperparathyroidism in MEN1 patients: preferred surgical procedure and relation with genotype

Thr300Ala ATG16L1 polymorphism influences susceptibility to and the prognosis of epithelial cell derived thyroid carcinoma

Quality of life is impaired in association with the need for prolonged postoperative therapy by somatostatin analogs in patients with acromegaly

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